Snakebite — Slay the Spire 2
Snakebite is a core poison card for Silent builds. It deals immediate damage while applying poison stacks, making it one of the most efficient early-game poison cards in Slay the Spire 2.
Card Stats
Why Snakebite is Strong
Efficient Poison Application
3 poison for 1 energy is excellent value. Most poison cards cost 1-2 energy for similar poison amounts, but Snakebite also deals immediate damage.
Common Rarity
Being Common means you'll see Snakebite frequently in card rewards and shops. Easy to build poison decks early in Act 1.
Immediate + Scaling Damage
Unlike pure poison cards, Snakebite deals 6 damage upfront. This helps in early fights where poison hasn't stacked yet.
Scales Into Late Game
With Snecko Skull relic, Snakebite applies 4 poison (5 upgraded). Combine with Catalyst for exponential poison growth.
Best Synergy Cards
Deadly Poison
Apply 5 poison. Stacks with Snakebite for fast poison buildup.
Noxious Fumes
Power that applies 2 poison to all enemies each turn. Passive poison engine.
Catalyst
Doubles poison on target. Snakebite sets up the multiplier.
Envenom
Applies 1 poison when attacks deal unblocked damage. Snakebite triggers this.
Burst
Play a Skill twice. Double Snakebite = 6 damage + 6 poison.
Corpse Explosion
Deals damage equal to poison on target. Snakebite sets up the explosion.
Best Synergy Relics
Snecko Skull
Whenever you apply Poison, apply 1 additional Poison
Twisted Funnel
Apply 4 poison to all enemies at start of combat
Unsettling Lamp
First debuff card played each combat has double effect
When to Pick Snakebite
✓ Pick Snakebite When:
- • You're building a poison deck
- • You already have Deadly Poison or Noxious Fumes
- • You have Snecko Skull relic
- • You need efficient damage in Act 1
- • You're facing long fights (elites, bosses)
✗ Skip Snakebite When:
- • You're building Shiv spam deck
- • You're building Sly discard deck
- • You already have 3+ poison cards
- • Enemies have Artifact (blocks debuffs)
- • You need burst damage, not scaling
Pro Tips
▸ Play Snakebite early in fights to let poison stack over time
▸ Upgrade Snakebite at campfires if you're committing to poison build
▸ Combine with Burst to apply 6 poison in one turn (8 if upgraded)
▸ Against enemies with Artifact, use Snakebite to burn through Artifact stacks
▸ Snakebite works on ALL enemies, making it strong in multi-enemy fights
Frequently Asked Questions
What does Snakebite do in Slay the Spire 2?
Snakebite is a Common Skill card for Silent that costs 1 energy. It deals 6 damage and applies 3 poison to a single enemy. When upgraded, it deals 9 damage and applies 4 poison.
Is Snakebite good?
Yes. Snakebite is one of the best early poison cards for Silent. It's common rarity means you'll see it often, and it provides both immediate damage and poison scaling in one card.
Should I upgrade Snakebite?
Yes, if you're building poison. The upgrade adds +3 damage and +1 poison, making it significantly stronger. Prioritize upgrading it in Act 1 if you're committing to poison build.
Does Snakebite work with Catalyst?
Yes. Snakebite applies poison, then Catalyst doubles all poison on the target. This combo is core to poison builds.